APRScience is an educational project presenting the medical evidence supporting Abortion Pill Reversal therapy

APR therapy has reversed over 5000 abortions in 93 countries

Abortion Pill Reversal (APR) is a safe and effective therapy that reverses the abortive effect of mifepristone. APR gives women a chance to change their mind after taking the abortion pill. This therapy has reversed over 5000 abortions in 93 countries. Women seeking access to APR therapy should visit Abortion Pill Reversal. Physicians seeking to join the APR medical network should visit APRN Worldwide.

APR Therapy
APR therapy involves giving the mother progesterone by a capsule or injection. APR increases progesterone concentration levels to better compete with mifepristone and restore a normal pregnancy. Research shows that 66% of women who receive progesterone soon after starting the abortion pill can safely continue their pregnancies. Download APR Fact Sheet.

APR Medical Evidence
Every APR clinical trial, observational study, and animal investigation has consistently shown that APR is safe and effective. Since 2012, three case series (Delgado 2012; Garratt 2017; Delgado 2018) and two clinical trials (Creinin 2020; Turner 2023) have studied APR therapy in humans. The research shows that two-thirds (66%) of women who change their minds and receive progesterone after starting medication abortion with mifepristone can safely continue their pregnancies.

The chart above presents the results of these studies. The vertical axis shows the continuing pregnancy rate (CPR) reported by each study, broken down by dosing and delivery regime. For instance, Delgado 2018e shows the CPR for oral administration of micronized progesterone (refer to data set 2 for details). The horizontal red line indicates the ≤25% CPR for mifepristone alone for ≤49 days gestation (refer to data set 1 for details). The research shows that the continuing pregnancy rate for mifepristone followed by progesterone is substantially higher than for mifepristone alone.

Informed Consent
Women who want to reverse their medication abortion must urgently receive progesterone after taking mifepristone. However, many women are unaware of APR treatment. Physicians who withhold APR information from women could cause a delay that leads to the death of her child as she searches for a way to reverse her medication abortion. Physicians should inform women of APR facts before they begin medication abortion.

Learn More
Learn more about the science that supports APR therapy by clicking on the Learn More buttons below. Refer to the Studies page to view APR research collections. The Resources page provides downloadable files and links to APR websites.

APRScience
APRScience is an educational project dedicated to analyzing and disseminating Abortion Pill Reversal medical evidence. APRScience supports clinicians and researchers who seek access to the latest APR science, providing easy-to-consume charts, figures, datasets, and research study collections.

The most common medication abortion regimen uses two drugs, mifepristone, and misoprostol. Mifepristone is a progesterone antagonist. Misoprostol triggers uterine contractions, expelling the embryo.

Clinicians can stop the effects of mifepristone by increasing progesterone concentration. The progesterone outcompetes mifepristone for the binding sites on the progesterone receptors.

The American Society for Reproductive Medicine reports no increased risk from using progesterone in early pregnancy. Physicians have safely used progesterone in reproductive medicine since the late 1970's.

Complete abortion (embryo demise, uterine evacuation), incomplete abortion (embryo demise, no/incomplete uterine evacuation), or continuing pregnancy (embryo survival).

Evidence from five studies since 2015 shows that the continuing pregnancy rate after ingesting mifepristone alone is generally below ≤25 percent for gestational age ≦49 days.

Evidence shows the continuing pregnancy rate after APR treatment is 65 percent or higher, well above the ≤25 percent continuing pregnancy rate for mifepristone alone.